Bisphosphonates are a class of drugs widely used, especially in patients with postmenopausal osteoporosis, that decrease bone resorption through different mechanisms of action. In recent years, several adverse effects have been associated with its long-term use. Major side effects include: osteonecrosis of the jaws, atypical fractures, musculoskeletal pain and atrial fibrillation. In addition, bisphosphonates can also induce inflammatory eye disorders, such as conjunctivitis, episcleritis and uveitis. This shows that some side effects are identified only after years of bisphosphonates chronic use in a wide population.